The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance
Curling - Clothing - Mens Abstract Background The dynamics of histone post-translational modifications (PTMs) are sparsely described, especially in their true physiological context of proteoforms (single histone molecules harboring combinations of PTMs).Methods Here we time-resolve the response of cells to SUV4-20 methyltransferase inhibition and u